EXPLORING THE INTERSECTION OF EPIGENETICS, DNA REPAIR, AND IMMUNOLOGY FROM STUDIES OF ICF SYNDROME, AN INBORN ERROR OF IMMUNITY

Exploring the intersection of epigenetics, DNA repair, and immunology from studies of ICF syndrome, an inborn error of immunity

Immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome, a rare autosomal recessive disorder, manifests with hypoglobulinemia and chromosomal instability accompanied by DNA hypomethylation.Pathological variants in the DNMT3B, ZBTB24, CDCA7, 1196 or HELLS genes underlie its etiology.Activated lymphocytes from patients often di

read more

Epistemic conservatism

The present paper aims to revisit the virtues and disadvantages of epistemic conservatism, which claims that it is rational to adhere to a belief Backpack until there is evidence to the contrary.Two main theses are put forward: first, while conservatism presents several epistemological Fabric Refreshers flaws, from a contextualist point of view it

read more